Rugarli lab - CECAD
REGULATION OF CLUH RECRUITMENT TO RNA GRANULES
Post-transcriptional regulation of the expression of nuclear-encoded mitochondrial proteins is still poorly understood. The evolutionary conserved CLUH (clustered mitochondrial homolog) protein binds a large subset of mRNAs encoding mitochondrial proteins involved in oxidative phosphorylation, the TCA cycle, beta-oxidation, and amino acid degradation. CLUH plays a crucial role in stabilizing these mRNAs and promoting their translation, thereby modulating mitochondrial metabolism. This project will address the dynamic localization of CLUH to RNA granules and potential regulatory mechanisms by using advanced microscopy and proteomics data.
Matteo Veronese
Graduated in October 2023
EMail: mverone1[at]uni-koeln.de
"I'm a cell molecular biologist from Italy. I moved to Germany for my PhD because of the vibrating scientific environment that Cologne offers. During my PhD I shed light on the molecular basis of the hereditary spastic paraplegia using cell culture models."
Publications
- CLUH controls astrin-1 expression to couple mitochondrial metabolism to cell cycle progression. Schatton D, Di Pietro G, Szczepanowska K, Veronese M, Marx MC, Braunöhler K, Barth E, Müller S, Giavalisco P, Langer T, Trifunovic A, Rugarli EI. Elife. 2022 May 13;11:e74552. doi: 10.7554/eLife.74552. PMID: 35559794
- Microtubule-dependent and independent roles of spastin in lipid droplet dispersion and biogenesis. Tadepalle N, Robers L, Veronese M, Zentis P, Babatz F, Brodesser S, Gruszczyk AV, Schauss A, Höning S, Rugarli EI. Life Sci Alliance. 2020 Apr 22;3(6):e202000715. doi: 10.26508/lsa.202000715. Print 2020 Jun. PMID: 32321733
Giada Di Pietro
PhD student since July 2020
EMail: gdipietr[at]uni-koeln.de
Publications
- CLUH controls astrin-1 expression to couple mitochondrial metabolism to cell cycle progression. Schatton D, Di Pietro G, Szczepanowska K, Veronese M, Marx MC, Braunöhler K, Barth E, Müller S, Giavalisco P, Langer T, Trifunovic A, Rugarli EI. Elife. 2022 May 13;11:e74552. doi: 10.7554/eLife.74552. PMID: 35559794
Selected Publications Rugarli lab
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Schatton, D. and E.I. Rugarli (2018), A concert of RNA-binding proteins coordinates mitochondrial function. Crit Rev Biochem Mol Biol. 53(6): p. 652-666.
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Schatton D, and Rugarli EI (2018). Post-transcriptional regulation of mitochondrial function. Curr Opin Physiol., 3, 6-15.
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Schatton, D., D. Pla-Martin, M.C. Marx, H. Hansen, A. Mourier, I. Nemazanyy, A. Pessia, P. Zentis, T. Corona, V. Kondylis, E. Barth, A.C. Schauss, V. Velagapudi, and E.I. Rugarli (2017), CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs. J Cell Biol. 216(3): p. 675-693.