UNIVERSITÄT ZU KÖLN

REGULATION OF CLUH RECRUITMENT TO RNA GRANULES

Post-transcriptional regulation of the expression of nuclear-encoded mitochondrial proteins is still poorly understood. The evolutionary conserved CLUH (clustered mitochondrial homolog) protein binds a large subset of mRNAs encoding mitochondrial proteins involved in oxidative phosphorylation, the TCA cycle, beta-oxidation, and amino acid degradation. CLUH plays a crucial role in stabilizing these mRNAs and promoting their translation, thereby modulating mitochondrial metabolism. This project will address the dynamic localization of CLUH to RNA granules and potential regulatory mechanisms  by using advanced microscopy and proteomics data.

PhD Student

adas8[at]uni-koeln.de

“I finished my Bachelor's degree in Microbiology from the University of Calcutta India, followed by a Master's degree in Biotechnology from the UNESCO-Regional Centre for Biotechnology, India. I then moved to Cologne, Germany to join Prof. Elena Rugarli's lab at the CECAD, University of Cologne as a 2nd cohort PhD student of the RTG2550 Reloc. I now study protein homeostasis at the endoplasmic reticulum and how perturbations to the quality control machineries can lead to debilitating neurodegenerative disorders.”

Publications

•  ERLIN1/2 scaffolds bridge TMUB1 and RNF170 and restrict cholesterol esterification to regulate the secretory pathway

  Life Science Alliance

  2024-05-23 | Journal article

  DOI: https://doi.org/10.26508/lsa.202402620

  CONTRIBUTORS: Matteo Veronese; Sebastian Kallabis; Alexander Tobias Kaczmarek; Anushka Das; Lennart Robers; Simon Schumacher; Alessia Lofrano; Susanne Brodesser; Stefan Mueller; Kay Hofmann et al.

•  A pH‐Sensitive Double Chromophore Fluorescent Dye for Live‐Tracking of Lipophagy

  Chemistry – A European Journal

  2024-04-22 | Journal article

  DOI: 10.1002/chem.202400808

  CONTRIBUTORS: Pascal M. Engelhardt; Matteo Veronese; Alpay A. Eryiğit; Anushka Das; Alexander T. Kaczmarek; Elena I. Rugarli; Hans‐Günther Schmalz

PhD Student

rparayil[at]uni-koeln.de

"I completed my Bachelor’s and Master’s studies at the Indian Institute  
of Science Education and Research (IISER) Tirupati, through the  
integrated BS-MS program. I specialised in Biology and developed an  
interest in Neurodegenerative diseases during my Master’s. I am now a  
PhD student in the Rugarli Lab, where I am focused on understanding  
the pathophysiology of Hereditary spastic paraplegia Type 7 caused by  
mutation in the SPG7 gene."
 

Publications

• CLUH controls astrin-1 expression to couple mitochondrial metabolism to cell cycle progression. Schatton D, Di Pietro G, Szczepanowska K, Veronese M, Marx MC, Braunöhler K, Barth E, Müller S, Giavalisco P, Langer T, Trifunovic A, Rugarli EI. Elife. 2022 May 13;11:e74552. doi: 10.7554/eLife.74552. PMID: 35559794

• Microtubule-dependent and independent roles of spastin in lipid droplet dispersion and biogenesis. Tadepalle N, Robers L, Veronese M, Zentis P, Babatz F, Brodesser S, Gruszczyk AV, Schauss A, Höning S, Rugarli EI. Life Sci Alliance. 2020 Apr 22;3(6):e202000715. doi: 10.26508/lsa.202000715. Print 2020 Jun. PMID: 32321733

Publications

• CLUH controls astrin-1 expression to couple mitochondrial metabolism to cell cycle progression. Schatton D, Di Pietro G, Szczepanowska K, Veronese M, Marx MC, Braunöhler K, Barth E, Müller S, Giavalisco P, Langer T, Trifunovic A, Rugarli EI. Elife. 2022 May 13;11:e74552. doi: 10.7554/eLife.74552. PMID: 35559794

Selected Publications Rugarli lab

• Schatton, D. and E.I. Rugarli (2018), A concert of RNA-binding proteins coordinates mitochondrial function. Crit Rev Biochem Mol Biol. 53(6): p. 652-666.

• Schatton D, and Rugarli EI (2018). Post-transcriptional regulation of mitochondrial function. Curr Opin Physiol., 3, 6-15.

• Schatton, D., D. Pla-Martin, M.C. Marx, H. Hansen, A. Mourier, I. Nemazanyy, A. Pessia, P. Zentis, T. Corona, V. Kondylis, E. Barth, A.C. Schauss, V. Velagapudi, and E.I. Rugarli (2017), CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs. J Cell Biol. 216(3): p. 675-693.