RTG reloc PhD Students

 

Giada Di Pietro (Rugarli lab)

• CLUH controls astrin-1 expression to couple mitochondrial metabolism to cell cycle progression. Schatton D, Di Pietro G, Szczepanowska K, Veronese M, Marx MC, Braunöhler K, Barth E, Müller S, Giavalisco P, Langer T, Trifunovic A, Rugarli EI. Elife. 2022 May 13;11:e74552. doi: 10.7554/eLife.74552. PMID: 35559794

Merlin Jan Klußmann (Neundorf lab)

• AIFM1 is a component of the mitochondrial disulfide relay that drives complex I assembly through efficient import of NDUFS5. Salscheider SL, Gerlich S, Cabrera-Orefice A, Peker E, Rothemann RA, Murschall LM, Finger Y, Szczepanowska K, Ahmadi ZA, Guerrero-Castillo S, Erdogan A, Becker M, Ali M, Habich M, Petrungaro C, Burdina N, Schwarz G, Klußmann M, Neundorf I, Stroud DA, Ryan MT, Trifunovic A, Brandt U, Riemer J. EMBO J. 2022 Jul 20:e110784. doi: 10.15252/embj.2022110784. Online ahead of print. PMID: 35859387

• Macropinocytosis-Inducible Extracellular Vesicles Modified with Antimicrobial Protein CAP18-Derived Cell-Penetrating Peptides for Efficient Intracellular Delivery. Noguchi K, Obuki M, Sumi H, Klußmann M, Morimoto K, Nakai S, Hashimoto T, Fujiwara D, Fujii I, Yuba E, Takatani-Nakase T, Neundorf I, Nakase I. Mol. Pharmaceutics 2021, 18, 9, 3290–3301 2021 Aug 8.doi: 10.1021/acs.molpharmaceut.1c00244

• Molecular Plasticity of Crystalline CK2α' Leads to KN2, a Bivalent Inhibitor of Protein Kinase CK2 with Extraordinary Selectivity. Lindenblatt D, Applegate V, Nickelsen A, Klußmann M, Neundorf I, Götz C, Jose J, Niefind K. J Med Chem. 2021 Jul 29. doi: 10.1021/acs.jmedchem.1c00063. PMID: 34323071

• Recent Advances and Trends in Chemical CPP-Drug Conjugation Techniques. (Review) Gayraud F, Klußmann M, Neundorf I. Molecules. 2021 Mar 13;26(6):1591. doi: 10.3390/molecules26061591. PMID: 3380568

• Interdependence of charge and secondary structure on cellular uptake of cell penetrating peptide functionalized silica nanoparticles. Gessner G, Klimpel A, Klußmann M, Neundorf I, Mathur S. Nanoscale Adv., 2020, 2, 453-462. doi: 10.1039/C9NA00693A

Pascal Engelhardt (Schmalz lab)

• Synthetic α-Helical Peptides as Potential Inhibitors of the ACE2 SARS-CoV-2 Interaction. Engelhardt, P..M., Rueda, S..F., Drexelius, M., Neudörfl, J., Lauster, D., Hackenberger, C..P.R., Kühne, R., Neundorf, I. and Schmalz, H. (2022), Chembiochem. 2022 Jul 4:e202200372. doi: 10.1002/cbic.202200372. Online ahead of print. PMID: 35785462

Konstantin Weiss (Riemer lab)

• A two-step mitochondrial import pathway couples the disulfide relay with matrix complex I biogenesis. Peker E, Weiss K, Song J, Zarges C, Gerlich S, Boehm V, Trifunovic A, Langer T, Gehring NH, Becker T, Riemer J. J Cell Biol. 2023 Jul 3;222(7):e202210019. doi: 10.1083/jcb.202210019. Epub 2023 May 9. PMID: 37159021

• Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair. Bolgi O, Silva-Garcia M, Ross B, Pilla E, Kari V, Killisch M, Spitzner M, Stark N, Lenz C, Weiss K, Donzelli L, Gorrell MD, Grade M, Riemer J, Urlaub H, Dobbelstein M, Huber R, Geiss-Friedlander R. EMBO Rep. 2022 Aug 1:e54136. doi: 10.15252/embr.202154136. Online ahead of print. PMID: 35912982

Associated RTG reloc PhD Students

Theresa Bock (Krüger lab)

• FGF21 modulates mitochondrial stress response in cardiomyocytes only under mild mitochondrial dysfunction. Croon M, Szczepanowska K, Popovic M, Lienkamp C, Senft K, Brandscheid CP, Bock T, Gnatzy-Feik L, Ashurov A, Acton RJ, Kaul H, Pujol C, Rosenkranz S, Krüger M, Trifunovic A Sci Adv. 2022 Apr 8;8(14):eabn7105. doi: 10.1126/sciadv.abn7105. Epub 2022 Apr 6. PMID: 35385313

• Low kindlin-3 levels in osteoclasts of kindlin-3 hypomorphic mice result in osteopetrosis due to leaky sealing zones. Klapproth S, Richter K, Türk C, Bock T, Bromberger T, Dominik J, Huck K, Pfaller K, Hess MW, Reichel CA, Krüger M, Nakchbandi IA, Moser M. J Cell Sci. 2021 Oct 27:jcs.259040. doi: 10.1242/jcs.259040. Online ahead of print. PMID: 34704600

• PERM1 interacts with the MICOS-MIB complex to connect the mitochondria and sarcolemma via ankyrin B. Bock T, Türk C, Aravamudhan S, Keufgens L, Bloch W, Rozsivalova DH, Romanello V, Nogara L, Blaauw B, Trifunovic A, Braun T, Krüger M. Nat Commun. 2021 Aug 12;12(1):4900. doi: 10.1038/s41467-021-25185-3. PMID: 34385433

• Phosphoproteomics of the developing heart identifies PERM1 - An outer mitochondrial membrane protein. Aravamudhan S, Türk C, Bock T, Keufgens L, Nolte H, Lang F, Krishnan RK, König T, Hammerschmidt P, Schindler N, Brodesser S, Rozsivalova DH, Rugarli E, Trifunovic A, Brüning J, Langer T, Braun T, Krüger M. J Mol Cell Cardiol. 2021 May;154:41-59. doi: 10.1016/j.yjmcc.2021.01.010. Epub 2021 Feb 5. PMID: 33549681

• Exercise-dependent increases in protein synthesis are accompanied by chromatin modifications and increased MRTF-SRF signalling. Solagna F, Nogara L, Dyar KA, Greulich F, Mir AA, Türk C, Bock T, Geremia A, Baraldo M, Sartori R, Farup J, Uhlenhaut H, Vissing K, Krüger M, Blaauw B. Acta Physiol (Oxf). 2020 Sep;230(1):e13496. doi: 10.1111/apha.13496. Epub 2020 May 30. PMID: 32408395

• High-throughput proteomics fiber typing (ProFiT) for comprehensive characterization of single skeletal muscle fibers. Kallabis S, Abraham L, Müller S, Dzialas V, Türk C, Wiederstein JL, Bock T, Nolte H, Nogara L, Blaauw B, Braun T, Krüger M. Skelet Muscle. 2020 Mar 23;10(1):7. doi: 10.1186/s13395-020-00226-5. PMID: 32293536

Nele Burdina (Schwarz lab)

• AIFM1 is a component of the mitochondrial disulfide relay that drives complex I assembly through efficient import of NDUFS5. Salscheider SL, Gerlich S, Cabrera-Orefice A, Peker E, Rothemann RA, Murschall LM, Finger Y, Szczepanowska K, Ahmadi ZA, Guerrero-Castillo S, Erdogan A, Becker M, Ali M, Habich M, Petrungaro C, Burdina N, Schwarz G, Klußmann M, Neundorf I, Stroud DA, Ryan MT, Trifunovic A, Brandt U, Riemer J. EMBO J. 2022 Jul 20:e110784. doi: 10.15252/embj.2022110784. Online ahead of print. PMID: 35859387

• Improving Membrane Activity and Cargo Delivery Efficacy of a Cell-Penetrating Peptide by Loading with Carboranes. Lützenburg T, Burdina N, Scholz MS, Neundorf I. Pharmaceutics. 2021 Dec 3;13(12):2075. doi: 10.3390/pharmaceutics13122075. PMID: 34959356

Judith Bruns (Schmalz lab)

• Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells. Barone M, Müller M, Chiha S, Ren J, Albat D, Soicke A, Dohmen S, Klein M, Bruns J, van Dinther M, Opitz R, Lindemann P, Beerbaum M, Motzny K, Roske Y, Schmieder P, Volkmer R, Nazaré M, Heinemann U, Oschkinat H, Ten Dijke P, Schmalz HG, Kühne R. Proc Natl Acad Sci U S A. 2020 Nov 24;117(47):29684-29690. doi: 10.1073/pnas.2007213117. Epub 2020 Nov 12. PMID: 33184177

Lennard-Maximilian Döring (Dohmen lab)

• Hypusinated eIF5A Promotes Ribosomal Frameshifting during Decoding of ODC Antizyme mRNA in Saccharomyces cerevisiae. Halwas K, Döring LM, Oehlert FV, Dohmen RJ. Int J Mol Sci. 2022 Oct 26;23(21):12972. doi: 10.3390/ijms232112972. PMID: 36361762

Sarah Gerlich (Riemer lab)

• The Orf9b protein of SARS-CoV-2 modulates mitochondrial protein biogenesis. Lenhard S*, Gerlich S*, Khan A, Rödl S, Bökenkamp JE, Peker E, Zarges C, Faust J, Storchova Z, Räschle M, Riemer J, Herrmann JM.J Cell Biol. 2023 Oct 2;222(10):e202303002. doi: 10.1083/jcb.202303002. Epub 2023 Sep 8. PMID: 37682539 (*authors contributed equally)

• A two-step mitochondrial import pathway couples the disulfide relay with matrix complex I biogenesis. Peker E, Weiss K, Song J, Zarges C, Gerlich S, Boehm V, Trifunovic A, Langer T, Gehring NH, Becker T, Riemer J. J Cell Biol. 2023 Jul 3;222(7):e202210019. doi: 10.1083/jcb.202210019. Epub 2023 May 9. PMID: 37159021

• AIFM1 is a component of the mitochondrial disulfide relay that drives complex I assembly through efficient import of NDUFS5. Salscheider SL, Gerlich S, Cabrera-Orefice A, Peker E, Rothemann RA, Murschall LM, Finger Y, Szczepanowska K, Ahmadi ZA, Guerrero-Castillo S, Erdogan A, Becker M, Ali M, Habich M, Petrungaro C, Burdina N, Schwarz G, Klußmann M, Neundorf I, Stroud DA, Ryan MT, Trifunovic A, Brandt U, Riemer J. EMBO J. 2022 Jul 20:e110784. doi: 10.15252/embj.2022110784. Online ahead of print. PMID: 35859387

• Proteasomal degradation induced by DPP9-mediated processing competes with mitochondrial protein import. Finger Y, Habich M, Gerlich S, Urbanczyk S, van de Logt E, Koch J, Schu L, Lapacz KJ, Ali M, Petrungaro C, Salscheider SL, Pichlo C, Baumann U, Mielenz D, Dengjel J, Brachvogel B, Hofmann K, Riemer J. EMBO J. 2020 Oct 1;39(19):e103889. doi: 10.15252/embj.2019103889. Epub 2020 Aug 20. PMID: 32815200

 

Esra Peker (Riemer lab)

• A two-step mitochondrial import pathway couples the disulfide relay with matrix complex I biogenesis. Peker E, Weiss K, Song J, Zarges C, Gerlich S, Boehm V, Trifunovic A, Langer T, Gehring NH, Becker T, Riemer J. J Cell Biol. 2023 Jul 3;222(7):e202210019. doi: 10.1083/jcb.202210019. Epub 2023 May 9. PMID: 37159021

• AIFM1 is a component of the mitochondrial disulfide relay that drives complex I assembly through efficient import of NDUFS5. Salscheider SL, Gerlich S, Cabrera-Orefice A, Peker E, Rothemann RA, Murschall LM, Finger Y, Szczepanowska K, Ahmadi ZA, Guerrero-Castillo S, Erdogan A, Becker M, Ali M, Habich M, Petrungaro C, Burdina N, Schwarz G, Klußmann M, Neundorf I, Stroud DA, Ryan MT, Trifunovic A, Brandt U, Riemer J. EMBO J. 2022 Jul 20:e110784. doi: 10.15252/embj.2022110784. Online ahead of print. PMID: 35859387

• Mitochondria shed their outer membrane in response to infection-induced stress. Li X, Straub J, Medeiros TC, Mehra C, den Brave F, Peker E, Atanassov I, Stillger K, Michaelis JB, Burbridge E, Adrain C, Münch C, Riemer J, Becker T, Pernas LF. Science. 2022 Jan 14;375(6577):eabi4343. doi: 10.1126/science.abi4343. Epub 2022 Jan 14. PMID: 35025629

• Erv1 and Cytochrome c Mediate Rapid Electron Transfer via A Collision-Type Interaction. Peker E, Erdogan AJ, Volkov AN, Riemer J. J Mol Biol. 2021 Jul 23;433(15):167045. doi: 10.1016/j.jmb.2021.167045. Epub 2021 May 8. PMID: 33971209

• The C-terminal region of the oxidoreductase MIA40 stabilizes its cytosolic precursor during mitochondrial import. Murschall LM, Gerhards A, MacVicar T, Peker E, Hasberg L, Wawra S, Langer T, Riemer J. BMC Biol. 2020 Aug 6;18(1):96. doi: 10.1186/s12915-020-00824-1. PMID: 32762682

• Protein Import Assay into Mitochondria Isolated from Human Cells. Murschall LM, Peker E, MacVicar T, Langer T, Riemer J. Bio Protoc. 2021 Jun 20;11(12):e4057. doi: 10.21769/BioProtoc.4057. eCollection 2021 Jun 20. PMID: 34263000

 

Katharina Stillger (Neundorf lab)

• Mitochondria shed their outer membrane in response to infection-induced stress. Li X, Straub J, Medeiros TC, Mehra C, den Brave F, Peker E, Atanassov I, Stillger K, Michaelis JB, Burbridge E, Adrain C, Münch C, Riemer J, Becker T, Pernas LF. Science. 2022 Jan 14;375(6577):eabi4343. doi: 10.1126/science.abi4343. Epub 2022 Jan 14. PMID: 35025629

• Cell-permeable CaaX-peptides affect K-Ras downstream signaling and promote cell death in cancer cells. Klimpel A, Stillger K, Wiederstein JL, Krüger M, Neundorf I. FEBS J. 2021 May;288(9):2911-2929. doi: 10.1111/febs.15612. Epub 2020 Nov 7. PMID: 33112492

 

Matteo Veronese (Rugarli lab)

• CLUH controls astrin-1 expression to couple mitochondrial metabolism to cell cycle progression. Schatton D, Di Pietro G, Szczepanowska K, Veronese M, Marx MC, Braunöhler K, Barth E, Müller S, Giavalisco P, Langer T, Trifunovic A, Rugarli EI. Elife. 2022 May 13;11:e74552. doi: 10.7554/eLife.74552. PMID: 35559794

• Microtubule-dependent and independent roles of spastin in lipid droplet dispersion and biogenesis. Tadepalle N, Robers L, Veronese M, Zentis P, Babatz F, Brodesser S, Gruszczyk AV, Schauss A, Höning S, Rugarli EI. Life Sci Alliance. 2020 Apr 22;3(6):e202000715. doi: 10.26508/lsa.202000715. Print 2020 Jun. PMID: 32321733