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Dohmen lab - Institute for Genetics


Protein modification with the small ubiquitin-related modifier (SUMO) is an essential reversible regulatory mechanism in eukaryotic cells known to cross-talk to other PTMs such as ubiquitylation, phosphorylation, and acetylation. Fluorescent reporter proteins fused to SUMO chains are strongly enriched in the cell nucleus. The goal of this project is to elucidate the mechanism of polysumoylation-mediated nuclear translocation and to investigate its reversibility.

Friederike Profe

PhD student since April 2020

EMail: fprofe1[at]

"I am Friederike and currently doing my PhD in the group of Prof. Dohmen. Before, I studied Biochemistry in Jena and Cologne. My main interest is the regulation of cellular mechanisms, many of which are controlled through intricate cascades and rely on precise modification of proteins. Those control mechanisms open up a very fascinating world, of which I love being able to explore a small fraction during my PhD."

Lennard-Maximilian Döring

PhD student since July 2017

EMail: doeringl[at]

"I studied biology at the university of Cologne, with a focus on genetics and microbiology. Fortunately, I had the opportunity to pursue my master's project in the Dohmen Lab, in which we aimed to understand the dynamic modification of proteins with the Small Ubiquitin-like modifier (SUMO)."


  • Hypusinated eIF5A Promotes Ribosomal Frameshifting during Decoding of ODC Antizyme mRNA in Saccharomyces cerevisiae. Halwas K, Döring LM, Oehlert FV, Dohmen RJ. Int J Mol Sci. 2022 Oct 26;23(21):12972. doi: 10.3390/ijms232112972. PMID: 36361762

  • Methods to study SUMO dynamics in yeast. Pabst S, Döring LM, Petreska N, Dohmen RJ. Methods Enzymol. 2019;618:187-210. doi: 10.1016/bs.mie.2018.12.026. Epub 2019 Feb 11. PMID: 30850052

Selected Publications Dohmen lab

  • Pabst, S., L.M. Döring, N. Petreska, R.J. Dohmen (2019), Methods to study SUMO dynamics in yeast. Methods Enzymol. 618: p.  187-210. 
  • Eckhoff, J. and R.J. Dohmen (2015), In Vitro Studies Reveal a Sequential Mode of Chain Processing by the Yeast SUMO (Small Ubiquitin-related Modifier)-specific Protease Ulp2. J Biol Chem. 290(19): p. 12268-81.
  • Sriramachandran, A.M., and R.J. Dohmen (2014), SUMO-targeted ubiquitin ligases. Biochim Biophys Acta.1843(1): p. 75-85.