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DESIGN OF CELL-PERMEABLE TOOLS TO STUDY CYSTEINE PRENYLATION

Within this project we aim to develop novel tools to study cysteine prenylation, which is mediated in the first step by prenyltransferases. The doctoral candidate will investigate the interaction of cell-permeable peptides with prenyltransferases in cell-free and cellular systems. Techniques applied vary from chemical peptide and recombinant protein synthesis to biophysical (e.g. protein-protein interaction) and cellular (e.g. uptake, cell viability) assays.

Selected Publications

  • Gronewold, A., M. Horn, and I. Neundorf (2018), Design and biological characterization of novel cell-penetrating peptides preferentially targeting cell nuclei and subnuclear regions. Beilstein J Org Chem. 14: p. 1378-1388.

  • Klimpel, A. and I. Neundorf (2018), Bifunctional peptide hybrids targeting the matrix of mitochondria. J Control Release. 291: p. 147-156.

  • Horn, M. and I. Neundorf (2018), Design of a novel cell-permeable chimeric peptide to promote wound healing. Sci Rep. 8: p. 16279.