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Insulin secretion induces the activation of the insulin-signaling pathway resulting in a translocation of GLUT4 vesicles to the plasma membrane facilitating glucose influx into the cell. The project will be focused on the characterization of insulin-dependent activation of E3 ligases and will decipher how protein ubiquitylation modulates the localization of signaling molecules and cellular vesicles. The project will use cutting-edge mass spectrometry and bioinformatics to show that reversible PTMs and transient protein-protein interactions are associated with changes of the GLUT4 localization after insulin stimulation.

Selected Publications

  • Jachimowicz, R.D., F. Beleggia, J. Isensee, B.B. Velpula, J. Goergens, M.A. Bustos, M.A. Doll, A. Shenoy, C. Checa-Rodriguez, J.L. Wiederstein, K. Baranes-Bachar, C. Bartenhagen, F. Hertwig, N. Teper, T. Nishi, A. Schmitt, F. Distelmaier, H.J. Ludecke, B. Albrecht, M. Krüger, B. Schumacher, T. Geiger, D.S.B. Hoon, P. Huertas, M. Fischer, T. Hucho, M. Peifer, Y. Ziv, H.C. Reinhardt, D. Wieczorek, and Y. Shiloh (2019), UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors. Cell. 176(3): p. 505-519 e22.

  • Nolte, H., T.D. MacVicar, F. Tellkamp, and M. Krüger (2018), Instant Clue: A Software Suite for Interactive Data Visualization and Analysis. Sci Rep. 8(1): p. 12648.

  • Brandt, C., H. Nolte, S. Henschke, L. Engstrom Ruud, M. Awazawa, D.A. Morgan, P. Gabel, H.G. Sprenger, M.E. Hess, S. Gunther, T. Langer, K. Rahmouni, H. Fenselau, M. Krüger, and J.C. Bruning (2018), Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation. Cell. 175(5): p. 1321-1335 e20.